Unlocking Hope: How Hyaluronic Acid Can Transform PCOS Management – Expert Insights from Dr Mozhgan

A Brief Look at Polycystic Ovary Syndrome [PCOS] 

Polycystic ovary syndrome or PCOS is one of the most common hormonal disorders affecting women across the globe. It primarily affects women during their reproductive age. While the exact cause of PCOS is unknown, it is believed to be caused by a combination of genetic and environmental factors. 

Some of the key features or symptoms of PCOS includes: 

1. Irregular menstrual cycles: Women with PCOS often experience irregular periods which may manifest as infrequent or prolonged cycles.  
2. Ovulatory dysfunction: PCOS affects the normal ovulatory functions. This means that women with PCOS do not ovulate or ovulate infrequently causing infertility. PCOS is one of the leading causes of infertility in women. 
3. Hyperandrogenism: In PCOS, there is an overproduction of androgens, a male sex hormone like testosterone. As a result, women may experience male-pattern baldness, excess facial or body hair, and severe acne. 
4. Polycystic ovaries: In some cases, women with PCOS may have ovaries that appear enlarged and contain small fluid-filled sacs or cysts. 

In addition to these symptoms, PCOS can also increase the risk of developing other health concerns later in life including type 2 diabetes, high blood pressure, heart problems, and endometrial cancer. 

Causes of PCOS 

As mentioned earlier, the root cause of PCOS is still unknown. However, some of the factors that can contribute to the development of PCOS are: 

1. Genetic factors: PCOS sometimes runs in families, suggesting that there may be a genetic predisposition to PCOS. 
2. Insulin resistance: Insulin resistance is when the body’s cell doesn’t respond effectively to insulin, which is common in PCOS. This can lead to elevated insulin levels which may exacerbate symptoms. 
3. Hormonal imbalance: Women with PCOS is often found to have an imbalance in reproductive hormones, including increased levels of luteinizing hormone [LH] and testosterone. 
4. Excess androgen: With PCOS, ovaries may produce elevated levels of androgen, which can lead to excess hair growth, acne, and infertility. 
5. Inflammation: Studies show that women with PCOS have a type of long-term low-grade inflammation that fuels polycystic ovaries to produce androgens. 

PCOS and Its Impact on Fertility & Overall Health 

PCOS can have a significant impact on a woman’s fertility and overall health. Here’s a quick glance at how PCOS affects these two factors: 

1. Fertility 

• PCOS primarily affects fertility through ovulatory dysfunction. As women with PCOS experience infrequent or absent ovulation, it makes it challenging for them to conceive. Since ovulation and menstruation is irregular, a majority of women with PCOS seek treatment. It is possible to treat infertility caused by PCOS through medications that induce ovulation or vitro fertilization [IVF].  

2. Overall Health 

• PCOS is associated with a range of metabolic and psychological health concerns, including hormonal imbalances, insulin resistance, metabolic abnormalities, risk of infertility, type 2 diabetes, and cardiovascular diseases. In addition to health concerns, PCOS can also impact mental well-being by increasing the risk of mood disorders and depression. 

In summary, PCOS impacts fertility mainly through ovulatory dysfunction, and it can cause a range of other health concerns. It’s essential for women with PCOS to get adequate treatment and support. 

Systemic Hyaluronic Acid and Female Health 

Hyaluronic acid [HA] is a naturally occurring substance found in our bodies and various tissues, including the skin, eyes, and joints. It acts as a cushion and lubricant in the joints and plays a crucial role in maintaining tissue hydration, wound repair, cell migration, and elasticity. 

In recent years, hyaluronic acid has gained popularity in skincare and medical treatments. 

What is Systemic Hyaluronic Acid? 

Systemic hyaluronic acid refers to the administration of hyaluronic acid through areas that allow its distribution throughout the body. While it’s more commonly used in skincare products and dermal fillers, there is ongoing research on how to expand its purpose and understand its potential benefits and risks. 

Benefits of Systemic Hyaluronic Acid 

1. Skin Hydration: When taken topically, systemic hyaluronic acid can help retain moisture and promote skin suppleness, making it a popular ingredient in skincare. 
2. Joint Health: Hyaluronic acid is an essential component for lubrication and shock absorption. Getting hyaluronic acid supplements can help reduce joint pain and inflammation in the joints. 
3. Wound Healing: Hyaluronic acid plays an essential role in wound healing by controlling inflammation and redirecting blood flow. Systemic supplementation can help heal wounds and repair damaged tissues. 
4. Eye Health: Hyaluronic acid eye drops can relieve dry eyes by providing lubrication and moisture. 
5. Vaginal Health: Hyaluronic acid can also help combat vaginal dryness by providing sufficient lubrication and moisture to the vaginal area. 

Systemic Hyaluronic Acid & PCOS 

While rigorous studies are necessary to establish a solid link between systemic hyaluronic acid and PCOS, the few studies we have now suggests that women with PCOS have a different composition of hyaluronic acid compared to women with regular period cycles. This implies that hyaluronic acid plays an important role in regulating period and that the dysregulated amount of hyaluronic acid in women with PCOS may contribute to their symptoms. 

Additionally, another research on 52 patients with primary ovarian insufficiency [POI] found that hyaluronic acid may play a role in preventing POI by contributing to maintain normal function of the ovarian cells. The study also suggests that hyaluronic acid could be a possible treatment for primary ovarian insufficiency. 

From the studies, we understand that hyaluronic acid can be a good supplement for women with PCOS as it improves some of its symptoms. When starting a new supplement regimen, it’s always essential to consult a healthcare professional to determine if it’s best for you. You can also get hyaluronic acid naturally through foods like cucumbers, tomatoes, potatoes, and oranges. 

In addition to taking hyaluronic supplements, it’s also essential to address hormonal imbalances, regulate stress, and follow a healthy lifestyle to manage PCOS. 

References

1. Singh, S., Pal, N., Shubham, S., Sarma, D.K., Verma, V., Marotta, F., & Kumar, M. (2023). Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics. Journal of Clinical Medicine, 12(4), 1454. Retrieved from Pubmed
2. Iaconisi, G.N., Lunetti, P., Gallo, N., Cappello, A.R., Fiermonte, G., Dolce, V., & Capobianco, L. (2023). Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications. International Journal of Molecular Sciences, 24(12), 10296. Retrieved from MDPI – Hyaluronic Acid Applications
3. Witchel SF, Oberfield SE, Peña AS. Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls. J Endocr Soc. 2019 Jun 14;3(8):1545-1573. doi: 10.1210/js.2019-00078. PMID: 31384717; PMCID: PMC6676075. Retrieved from NLM

Get Help with Dr. Mozhgan 

If you’re experiencing symptoms of PCOS, it’s best to consult a healthcare professional immediately. Consider Dr. Mozhgan, one of the best gynecologists in Dubai. With over 25 years of invaluable experience and expertise, she has all the tools required to help you treat PCOS. 

Book an appointment today and take control of your health!